A human lung tumor-associated antigen cross-reactive with alpha 1-antichymotrypsin.
نویسندگان
چکیده
منابع مشابه
Prostate-specific antigen in serum occurs predominantly in complex with alpha 1-antichymotrypsin.
Immunologic measurements of the serum concentration of prostate-specific antigen (PSA), an abundant prostatic-secreted serine proteinase, are frequently used to monitor patients with prostate cancer, though it has not been ascertained whether this immunoreactivity represents a PSA zymogen, the active proteinase, or PSA complexed to extracellular proteinase inhibitors. To characterize the PSA im...
متن کاملAlpha 1 antichymotrypsin genotype is associated with increased risk of prostate carcinoma and PSA levels.
BACKGROUND Prostate cancer (PCa) is the most common non-skin cancer among men in Western countries. Inflammation appears to be involved in the pathogenesis of PCa. Recent studies have shown that many inflammatory genes are associated with the risk of PCa. Alpha 1 antichymotrypsin (ACT) is an acute phase protein and it is part of the circulating prostate specific antigen (PSA). PATIENTS AND ME...
متن کاملReactive astrocytes and 1-antichymotrypsin in Alzheimer’s disease
There is ample genetic, biochemical, cellular and molecular evidence to show that the amyloid peptide (A ), a proteolytic fragment of the amyloid precursor protein (APP), plays an important, if not causative role in Alzheimer’s disease (AD). An additional hallmark of AD is the neuroinflammatory response that is associated with the amyloid deposition. We discovered that the acute phase protein 1...
متن کاملExpression of alpha-1-antichymotrypsin in prostate carcinoma.
Prostate specific antigen (PSA) is a glycoprotein with the enzymatic activity of serine protease, the gene which is encoded in the human glandular kallikrein gene locus. Catalytically active PSA released into serum may be inactivated by a complex formation with alpha 1ACT (ACT) and alpha 2MG (MG), two major protease inhibitors. The serum complex-to-total PSA ratio can be used as a marker for th...
متن کاملAlpha-1 protease inhibitor and antichymotrypsin levels in acute pancreatitis.
BACKGROUND Acute pancreatitis with high mortality of severe onset is still a major problem in medicine. Early identification of the severity of the disease is critical for effective treatment. Many markers have been tried and are still being tested. The ideal marker should be able to identify the cases and distinguish between mild and severe. METHODS This prospective study included 34 cases (...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1980
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)70651-6